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Allos Therapeutics

About Allos Therapeutics:

Allos Therapeutics, Inc. is a biopharmaceutical company focused on developing and commercializing innovative drugs for improving cancer treatments. The companyís lead clinical candidate, Efaproxiral, is a synthetic small molecule that has the potential to sensitize hypoxic (oxygen deprived) tumor tissues and enhance the efficacy of standard radiation therapy. Allos is currently in the process of submitting a New Drug Application (NDA) for Efaproxiral to the FDA for the treatment of patients with brain metastases from breast cancer.

In January 2003, Allos licensed PDX from the Memorial Sloan-Kettering Cancer Center, Southern Research Institute and SRI International. PDX is a novel small molecule cytotoxic injectable antifolate (DHFR inhibitor) that has enhanced potency and toxicity profile relatvie to methotrexate. It is being developed for non-small cell lung cancer, mesothelioma and non-Hodgkinís lymphoma.


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Phase ndaEfaproxiral Brain metastases from breast cancer
Phase IIIEfaproxiral Brain metastases from breast cancer
Phase IIEfaproxiral non-small cell lung cancer
Phase IIEfaproxiral cervical cancer
Phase IIEfaproxiral Recurent GBM/NABTT
Phase IIPDX (pralatrexate) plannednon-small cell lung cancer
Phase IIPDX (pralatrexate) Mesothelioma
Phase IIPDX (pralatrexate) non-Hodgkin's Lymphoma


NIH Trial (Phase III)for Efaproxiral

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